Official Journal of The Academy of Osseointegration
Human Histologic Evaluation of Anorganic Bovine Bone Mineral Combined with Recombinant Human Platelet-Derived Growth Factor BB in Maxillary Sinus Augmentation: Case Series Study
Myron Nevins, DDS/David Garber, DMD/James J. Hanratty, DDS/ Bradley S. McAllister, DDS/Marc L. Nevins, DMD, MMSc/Maurice Salama, DMD/Peter Schupbach, PhD/Steven Wallace, DDS/Simon M. Bernstein, DDS, MS/David M. Kim, DDS, DMSc
PMID: 20072735
DOI: 10.11607/prd.00.0891
The objective of this proof-of-principle study was to examine the potential for improved bone regenerative outcomes in maxillary sinus augmentation procedures when recombinant human platelet-derived growth factor BB (0.3 mg/mL) is combined with particulate anorganic bovine bone mineral. The surgical outcomes in all treated sites were uneventful at 6 to 8 months, with sufficient regenerated bone present to allow successful placement of maxillary posterior implants. Large areas of dense, well-formed lamellar bone were seen throughout the intact core specimens in more than half of the grafted sites. Abundant numbers of osteoblasts were noted in concert with significant osteoid in all sites, indicating ongoing osteogenesis. A number of cores demonstrated efficient replacement of the normally slowly resorbing anorganic bovine bone mineral matrix particles with newly formed bone when the matrix was saturated with recombinant human platelet-derived growth factor BB. (Int J Periodontics Restorative Dent 2009;29:583–591.)
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